{"id":3610,"date":"2025-08-18T13:24:32","date_gmt":"2025-08-18T13:24:32","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/evolution\/?p=3610"},"modified":"2025-08-20T14:44:48","modified_gmt":"2025-08-20T14:44:48","slug":"annie-hatmaker-explores-the-global-diversity-of-a-pathogenic-fungus","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/evolution\/annie-hatmaker-explores-the-global-diversity-of-a-pathogenic-fungus\/","title":{"rendered":"Annie Hatmaker Explores the Global Diversity of a Pathogenic Fungus"},"content":{"rendered":"

By Andy Flick, Evolutionary Studies scientific coordinator<\/em><\/p>\n

\"\"<\/a>
Hatmaker posing with the Evolutionary Studies outreach casts.<\/figcaption><\/figure>\n

Annie Hatmaker, Ph.D., has spent the better part of a decade studying fungi and their secondary metabolites \u2013 small molecules they use to communicate, defend, and thrive. Her new publication, \u201cPopulation structure in a fungal human pathogen is potentially linked to pathogenicity<\/a>,\u201d closes her dissertation work and opens up a world of possibilities. Her fungus of choice is the Aspergillus<\/em> genus, in this study, Aspergillus flavus<\/em>.<\/p>\n

This story is based on clinical and environmental data from more than a dozen countries. Using genomic methods on 300 collected isolates of A. flavus<\/em>, the team created an evolutionary tree suggesting that the isolates consist of five distinct populations.<\/p>\n

Hatmaker was excited about the potential research prospects offered by the A. flavus<\/em><\/span> system and other projects in her Ph.D. advisor Antonis Rokas’ lab<\/a>.<\/p>\n

\u201cSeveral studies had published whole-genome sequencing of Aspergillus flavus <\/em>isolates just as I was considering topics,\u201d she said. \u201cI was incredibly interested in how it was a human pathogen and also of agricultural interest due to its ability to produce aflatoxin (a type of secondary metabolite called a mycotoxin).\u201d<\/p>\n

Providing broader context on mycotoxins, collaborator from the Rokas Lab<\/a>, postdoctoral researcher Thomas Sauters, explained that mycotoxins are toxic chemical compounds produced naturally by certain fungi, including A. flavus<\/em>, which can contaminate crops such as corn, peanuts, and tree nuts. Aflatoxins are among the most potent naturally occurring carcinogens known, posing serious risks to human and animal health when ingested. Their production is influenced by environmental factors such as temperature, humidity, and nutrient availability, and while they are a major concern in agriculture, their role in human infections remains less clear.<\/p>\n

\"A<\/a>
Simplified reproduction of Figure 1B from the manuscript, showing five genetically distinct populations of Aspergillus flavus. Populations A, C, and D cluster closely, while Populations B and S are more divergent, reflecting global genetic diversity.<\/figcaption><\/figure>\n

\u201cWe know that aflatoxin production is reduced at the temperature of the human body, possibly indicating it is not necessary or important for human infections,\u201d explained Hatmaker. \u201cIn other studies, however, there\u2019s evidence that strains lacking the capability to produce aflatoxin are able to produce other metabolites which might play a role in infections. There\u2019s plenty of future work to be done regarding aflatoxin, so this remains a mystery!\u201d<\/p>\n

While working with a broad international dataset, Hatmaker also led a team of scientists from institutions across the U.S. and Europe, reflecting a broad transatlantic collaboration. Contributors came from 国产原创 (Hatmaker, Thomas Sauters, Adiyantra Gumilang, and Rokas), the USDA Agricultural Research Service, University of Wisconsin-Madison, and University of Texas in the United States; Friedrich Schiller University, Hans-Knoell-Institute, and the University of W\u00fcrzburg in Germany; Instituto de Salud Carlos III in Spain; and Institut Pasteur in France.<\/p>\n

Citation: Hatmaker, E.A., Barber, A.E., Drott, M.T.\u00a0et al.<\/i>\u00a0Population structure in a fungal human pathogen is potentially linked to pathogenicity.\u00a0Nat Commun<\/i>\u00a016<\/b>, 7594 (2025). https:\/\/doi.org\/10.1038\/s41467-025-62777-9<\/p>\n

Funding Statement: This work was partially funded by the National Institutes of Health\/National Eye Institute (F31 EY033235 to E.A.H.) and the National Institutes of Health\/National Institute of Allergy and Infectious Diseases (R01 AI153356 to A.R.). Research in A.R.\u2019s lab is also supported by the National Science Foundation (DEB-2110404) and the Burroughs Wellcome Fund. A.E.B is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research 358 Foundation) under Germany\u2019s Excellence Strategy\u2014EXC 20151\u2014Project-ID 390813860. M.T.D. is supported by the United States Department of Agriculture, Agricultural Research Service. Work of the German NRZMyk is supported by the Robert Koch Institute from funds provided by the German Ministry of Health (grant-No. 1369-240). A. A.-I. is supported by Fondo de Investigaciones Sanitarias from Instituto de Salud Carlos III (grant-No. PI20CIII\/00043).\u00a0N.P.K. and J.L.E. are supported by the National Institutes of Health\/National Institutes of General Medical Science (R01 GM112739 and R35 GM156119 to N.P.K.).<\/p>\n","protected":false},"excerpt":{"rendered":"

By Andy Flick, Evolutionary Studies scientific coordinator Annie Hatmaker, Ph.D., has spent the better part of a decade studying fungi and their secondary metabolites \u2013 small molecules they use to communicate, defend, and thrive. Her new publication, \u201cPopulation structure in a fungal human pathogen is potentially linked to pathogenicity,\u201d closes her dissertation work and opens…<\/p>\n","protected":false},"author":2421,"featured_media":3612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[56,29,13,14,16,128,15,3],"acf":[],"yoast_head":"\n\n\n\n\n\n\n\n\n\n\n\n\t\n\t\n\t\n\n\n\t\n\t\n\t\n