国产原创

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国产原创 Biophotonics Center

国产原创 Biophotonics Center
  2. People
  3. Karen Joos

Karen Joos

Research Focus

Applications of optical techniques for sensing and performing ophthalmic surgery. A听particular emphasis is the use of miniature optical coherence tomography probes for听surgical image guidance.

Lab Aims

The primary aim is to develop and deploy translatable听biophotonics technologies for ophthalmology.听A current emphasis is the development and integration of an听intraocular OCT probe to improve visualization of structures听during vitreoretinal and other ophthalmic surgery, as well as听the integration of these imaging probes with surgical tools and听robotic-assisted control for precise tissue manipulation. Past听approaches included; 1) the investigation of an OCT imaging听modality in eyes with elevated IOP and 2) integration of听intraocular endoscopy to improve visualization and facilitate听intraocular surgery in eyes with cloudy corneas. Approaches听include: histology, morphometry, immunohistochemistry,听intraocular pressure response, and biomaterial delivery.

Other bench and clinical projects are glaucoma-centered听research topics. Research collaborations are ongoing with听multidisciplinary investigators in ophthalmology, engineering,听and genetics.听

Lab Members

听 Name Email Role
听 Jin Hui Shen 听jin-hui.shen
Research Assistant Professor听
听 Ratna Prasad 听- Research Assistant, III听听

听

Publications

Tarantola RM, Agarwal A, Lu P, Joos KM. Long-term results of combined endoscope-assisted pars plana听vitrectomy and glaucoma tube shunt surgery. Retina, 31(2):275-283, 2011. PMCID: PMC3058695.

Kozub J, Ivanov B, Jayasinghe A, Prasad R, Shen J, Klosner M, Heller D, Mendenhall M, Piston D, Joos K,听Hutson MS. Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-飦璵 wavelength range.听Biomedical Optic Express, 2(5):1275-1281, 2011. PMCID: PMC3087584.

Yu H, Shen JH, Joos K, and Simaan N. Design, calibration and preliminary testing of a robotic听telemanipulator for OCT-guided retinal surgery. IEEE International Conference Proceedings on Robotics听and Automation (ICRA'2013), peer-reviewed paper, 2013: 225鈥231.

Joos KM, Shen JH. Miniature real-time intraoperative forward-imaging optical coherence tomography听probe. Biomedical Optics Express, 4(8):1342-1350, 2013. PMCID: PMC3756577.

Li Z, Shen J, Kozub J, Prasad R, Lu P, Joos K, A miniature forward-imaging B-scan optical coherence听tomography probe to guide real-time laser ablation. Lasers in Surgery and Medicine, 46(3):193-202,听2014. PMCID: PMC3962956.

Joos KM, Shen J. Preliminary design and evaluation of a B-scan OCT-guided 36-gauge needle tip.听Photonics, 1: 260-266; doi:10.3390/photonics1030260, 2014.

Yu H, Shen J, Shah R, Simaan N, Joos KM. Evaluation of microsurgical tasks with OCT-guided and/or听robot-assisted ophthalmic forceps. Biomedical Optics Express, 6(2): 457鈥472, 2015. PMID: 25780736.

Kozub JA, Shen JH, Joos KM, Prasad R, Hutson S. Efficacy and predictability of soft tissue ablation using a听prototype Raman-shifted alexandrite laser. J Biomedical Optics, 20(10):105004. doi:听10.1117/1.JBO.20.10.105004. PMID: 26456553.

Kozub J, Shen J, Joos KM, Prasad R, Hutson MS, Optic nerve sheath fenestration using a Raman-shifted听alexandrite laser. Lasers in Surgery and Medicine, 48(3):270-280, 2016, doi: 10.1002/lsm.22456. PMID:听27020001, PMC: 820007. --- Journal Cover Photo

Choh V, Gurdita A, Tan B, Prasad RC, Bizheva K, Joos KM. Short-term moderately elevated intraocular听pressure is associated with elevated scotopic electroretinogram responses. Investigative Ophthalmology听and Visual Science, 2016; 57(4): 2140-2151. doi: 10.1167/iovs.15-18770. PMID: 27100161.

Yu H, Shen JH, Joos KM, Simaan N. Calibration and integration of B-mode optical coherence tomography听for assistive control in robotic micro-surgery. Transactions in Mechatronics. 2016 June 22. [Epub ahead听of print], 2016; 21(6):2613-2623. doi: 10.1109/TMECH.2016.2583259.听
http://ieeexplore.ieee.org/document/7496970/.


Malone JD, El-Haddad MT, Bozic I, Tye LA, Majeau L, Godbout N, Rollins AM, Boudoux C, Joos KM, Patel听SN, Tao YK. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded听scanning laser ophthalmoscopy and optical coherence tomography. Biomed Opt Express. 2017;8(1):193-206. doi: 10.1364/BOE.8.000193. PMID: 28101411.

Del Giudice G, Wang L, Shen JH, Joos K, Simaan N. Continuum Robots for Multi-Scale Motion: Micro-Scale Motion through Equilibrium Modulation. Proceedings of the 2017 IEEE/RSJ International听Conference on Intelligent Robots and Systems (IROS 2017). Sept 2017, doi: 10.1109/IROS.2017.8206074.

Tan B, Gurdita A, Choh V, Joos K, Prasad R, Bizheva K. Morphological and functional changes in the rat听retina associated with 2 months of intermittent moderate intraocular pressure elevation. Scientific听Reports. 2018; 8:7727 (1-11) . doi:10.1038/s41598-018-25938-zwww.nature.com/articles/s41598-018-25938-z, PMID: 29769654.